Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity*
نویسندگان
چکیده
منابع مشابه
Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity*
Here, we report that the natural compound pentachloropseudilin (PClP) acts as a reversible and allosteric inhibitor of myosin ATPase and motor activity. IC(50) values are in the range from 1 to 5 μm for mammalian class-1 myosins and greater than 90 μm for class-2 and class-5 myosins, and no inhibition was observed with class-6 and class-7 myosins. We show that in mammalian cells, PClP selective...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.239210